Clorsulon
| CAS No. | 60200-06-8 | Cat. No. | BCP12136 |
| Name | Clorsulon | ||
| Synonyms | Curatrem;L631529;L 631529;L-631529;MK401;MK-401;MK 401; BRN 2821757; BRN2821757; BRN-2821757; | ||
| Formula | C8H8Cl3N3O4S2 | M. Wt | 380.66 |
| Description | Clorsulon is a competitive inhibitor of both 3-phosphoglycorate and ATP and had a Ki of 0.29 mM, inhibits glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. [1] Clorsulon (a single dose of 15 mg/kg) is effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep. Clorsulon causes severe disruption to the tegument and gut of Fasciola hepatica after in vivo incubation. | ||
| Pathways | Microbiology/Virology | ||
| Targets | Antiparasitics | ||
Structure
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