瑞巴匹特
| CAS号 | 111911-87-6 | 货号 | BCP12128 |
| 中文名 | 瑞巴匹特 | ||
| 英文名 | Rebamipide | ||
| 中文别名 | |||
| 英文别名 | OPC12759;OPC 12759;OPC-12759;Proamipide; | ||
| 分子式 | C19H15ClN2O4 | 分子量 | 370.79 |
| 生物活性 | Rebamipide is a quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an increase in endogenous prostaglandin synthesis in the gastric mucosa. This agent also inhibits H. pylori-induced production of tumor necrosis factor (TNF) alpha and subsequent inflammation of the gastric mucosa. In addition, rebamipide scavenges oxygen-derived free radicals that potentially cause mucosal injury, and stimulates prostaglandin EP4 receptor gene expression followed by mucous secretion, thereby enhancing the gastric mucosal defense. | ||
| 信号通路 | Neuro Signaling Pathway GPCR/G Protein | ||
| 靶 点 | Prostaglandin Receptor COX | ||
结构式
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