Ceftriaxone sodium sterile

CAS No.	104376-79-6	Cat. No.	BCP12159
Name	Ceftriaxone sodium sterile
Synonyms	Ceftriaxone disodium hemiheptahydrate;Ceftriaxone sodium hydrate;
Formula	C18H16N8O7S3.7/2H2O.2Na	M. Wt	661.6

Description	Ceftriaxone sodium hydrate is an antibiotic useful for the treatment of a number of bacterial infections; a third-generation cephalosporin.Ceftriaxone Sodium is the sodium salt form of ceftriaxone, a beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Ceftriaxone binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to the second and first generation cephalosporins, ceftriaxone is more active against gram-negative bacteria and less active against gram-positive bacteria. Ceftriaxone also crosses the blood-brain barrier and reaches therapeutic concentrations in the central nervous system (CNS).
Pathways	Microbiology/Virology
Targets	Antibiotic

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