Zebularine
| CAS No. | 3690-10-6 | Cat. No. | BCP12209 |
| Name | Zebularine | ||
| Synonyms | NSC309132;NSC-309132;NSC 309132;4-Deoxyuridine; | ||
| Formula | C9H12N2O5 | M. Wt | 228.2 |
| Description | Zebularine is a synthetic cytidine analogue and a cytidine deaminase inhibitor with anticancer activity. Following metabolic activation by phosphorylation and incorporation into DNA, zebularine inhibits DNA methyltransferase through covalent complex formation between the enzyme and zebularine-substituted DNA, hence resulting in non-specific, genome-wide induction of demethylation including the removal of aberrant methylation of promoter regions of genes critical for normal cellular functions. | ||
| Pathways | Others Pathway Epigenetics | ||
| Targets | DNA Methyltransferase Autophagy | ||
Structure
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