Ancitabine hydrochloride

CAS No.	10212-25-6	Cat. No.	BCP12373
Name	Ancitabine hydrochloride
Synonyms	Cyclocytidine hydrochloride;Cyclocytidine HCl;Cyclo-CMP hydrochloride;
Formula	C9H12ClN3O4	M. Wt	261.66

Description	Ancitabine Hydrochloride is the hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity. Upon administration, ancitabine is slowly hydrolyzed into cytarabine. Subsequently, cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. Cytarabine agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair. Compared to cytarabine, a more prolonged, consistent cytarabine-mediated therapeutic effect may be achieved with ancitabine because of the slow hydrolytic conversion of ancitabine to cytarabine.
Pathways	Cell Cycle/DNA Damage
Targets	DNA/RNA Synthesis

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