氯前列烯醇钠
| CAS号 | 62561-03-9 | 货号 | BCP12580 |
| 中文名 | 氯前列烯醇钠 | ||
| 英文名 | (+)-Cloprostenol sodium | ||
| 中文别名 | |||
| 英文别名 | |||
| 分子式 | C22H28ClNaO6 | 分子量 | 446.9 |
| 生物活性 | (+)-Cloprostenol is a synthetic analog of prostaglandin F2α (PGF2α). It is an FP receptor agonist and a potent luteolytic agent in rats and hamsters. (+)-Cloprostenol is the optically active, 15(R) enantiomer of cloprostenol accountable for the majority of its biological activity. Cloprostenol is 200 times and 100 times more potent than PGF2α in terminating pregnancy in hamsters and rats, respectively without the side effects associated with PGF2α. The subcutaneous dose required for interrupting early pregnancy is species dependent, requiring approximately 1.25 μg/kg and 270 μg/kg in hamsters and rats, respectively. Cloprostenol is also a potent inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 of 3 x 10-12 M. | ||
| 信号通路 | GPCR/G Protein | ||
| 靶 点 | Prostaglandin Receptor | ||
结构式
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