布美他尼
| CAS号 | 28395-03-1 | 货号 | BCP28485 |
| 中文名 | 布美他尼 | ||
| 英文名 | Bumetanide | ||
| 中文别名 | |||
| 英文别名 | Ro 10-6338; PF 1593；Ro-10-6338; PF1593；Ro10-6338; PF-1593; | ||
| 分子式 | C17H20N2O5S | 分子量 | 364.42 |
| 生物活性 | Bumetanide is a loop diuretic of the sulfamyl category to treat heart failure. It is often used in people in whom high doses of furosemide are ineffective. It is marketed by Hoffmann-La Roche. The main difference between the two substances is in bioavailability and pharmacodynamic potency. Furosemide is incompletely absorbed in the intestine (60%), and there are substantial inter- and intraindividual differences in bioavailability (range 10-90%). Bumetanide is almost completely absorbed (80%), and the absorption is not altered when it is taken with food. It is said to be a more predictable diuretic, meaning that the predictable absorption is reflected in a more predictable effect. | ||
| 信号通路 | Ion Channel/Membrane Transporter | ||
| 靶 点 | NKCC | ||
结构式
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