诃子宁
| CAS号 | 166833-80-3 | 货号 | BCP28487 |
| 中文名 | 诃子宁 | ||
| 英文名 | Chebulanin | ||
| 中文别名 | |||
| 英文别名 | Terminalic acid; | ||
| 分子式 | C27H24O19 | 分子量 | 652.47 |
| 生物活性 | Chebulanin is a topoisomerase I inhibitor. Chebulanin inhibits the calcineurin pathway in C. neoformans.Chebulanin exhibits potent antifungal activity against various human pathogenic fungi with minimum inhibitory concentrations ranging from 0.25 to over 64 μg/ml. Chebulanin suppresses the expression of inflammatory mediators and prevents cartilage destruction and bone erosion in mice, therefore, chebulanin is a strong therapeutic alternative for the treatment of rheumatism arthritis.Chebulanin shows strong radical scavenging activity, good potency to chelate Fe2⁺ and good inhibition ability of lipid peroxidation. Chebulanin has apparent capacities of inhibiting the survival of MCF-7 human cancer cell line. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | Topoisomerase | ||
结构式
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