ML265

CAS No.	1221186-53-3	Cat. No.	BCP12877
Name	ML265
Synonyms	ML 265;ML-265;TEPP-46;TEPP 46;TEPP46; CID44246499; CID-44246499; CID 44246499; NCGC00186528; NCGC 00186528; NCGC-00186528;
Formula	C17H16N4O2S2	M. Wt	372.46

Description	ML265 is a potent PKM2 activator induces tetramerization and reduces tumor formation and size in a mouse xenograft model. Cancer cells have altered metabolic processes compared to normal differentiated cells and the expression of the M2 isozyme of pyruvate kinase (PKM2) plays an important role in this aberrant metabolism. ML265 induces the more active tetrameric state of PKM2 and the X-ray co-crystal structure shows that the activator binds at the dimer-dimer interface between two subunits of PKM2. ML265 was tested in a H1299 mouse xenograft model and showed significant reduction in tumor size, weight, and occurrence with no apparent toxicity over the 7-week experiment.
Pathways	Protease/Metabolic Enzyme
Targets	Pyruvate Kinase

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