U73343
CAS号 | 142878-12-4 | 货号 | BCP12871 |
中文名 | U73343 | ||
英文名 | U73343 | ||
中文别名 | |||
英文别名 | U-73343;U 73343; | ||
分子式 | C29H42N2O3 | 分子量 | 466.66 |
生物活性 | U-73343 is a negative control (or inactive analogue) of U73122, which is a putative phospholipase C inhibitor. U73343 was found to inhibit TxA2 formation; it therefore partially inhibited the rise in [Ca2+]i evoked by low concentrations of thrombin, by thapsigargin or by collagen. U73343 had a greater effect than aspirin on the action of collagen, indicating an action on the TxA2-independent component of the signal, via PLC gamma-U73343 lowered TxA2 production by inhibiting the activation of cPLA2, probably at a tyrosine phosphorylation step. U73343 seems to inhibit only the tyrosine kinases involved in the activation of PLC gamma and the generation of TxA2. | ||
信号通路 | Protease/Metabolic Enzyme | ||
靶 点 | Phospholipase |
结构式
![](https://img.biochemsafebuy.com/uploads/img/142878-12-4_BCP12871.png)
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