TAPI1
| CAS No. | 163847-77-6 | Cat. No. | BCP12888 |
| Name | TAPI1 | ||
| Synonyms | TAPI-1;TAPI 1; | ||
| Formula | C26H37N5O5 | M. Wt | 499.6 |
| Description | TAPI-1 inhibited LL-37-induced TGF-α production, EGFR activation and subsequent MUC5AC mucin production, whereas TGF-α-neutralizing antibody, but not AR- or HB-EGF-neutralizing antibody, inhibited LL-37-induced EGFR activation and subsequent MUC5AC mucin production in NCI-H292 cells. Using the TNF-alpha converting enzyme (TACE) inhibitor, TAPI-1, TPA-stimulated TNFalpha shedding could be completely prevented in PKCepsilon transgenic mice and isolated keratinocytes. Pretreatment with antibody against FcγRII or with CD32 siRNA, p47(phox) siRNA, apocynin, N-acetylcysteine, tumor necrosis factor-α protease inhibitor 1 (TAPI-1) or TACE siRNA attenuated sLOX-1 release induced by CRP. CRP also elevated serum sLOX-1 levels in a rabbit model of atherosclerosis . | ||
| Pathways | Protease/Metabolic Enzyme Apoptosis Pathway | ||
| Targets | TNF Receptor MMP | ||
Structure
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