Dolastatin 10

CAS No.	110417-88-4	Cat. No.	BCP12967
Name	Dolastatin 10
Synonyms	DLS 10;DLS10;DLS-10;NSC 376128;NSC376128;NSC-376128;Dolastatin-10;Dolastatin10;
Formula	C42H68N6O6S	M. Wt	785.1

Description	Dolastatin 10 consists of four amino acids (in order from the amino terminus: dolavaline, valine, dolaisoleucine, and dolaproine), three unique to D. auricularia, linked to an unusual primary amine (dolaphenine, probably derived from phenylalanine) at what would otherwise be its carboxyl terminus. Monomethylauristatin E (MMAE) is a synthetic dolastatin 10 derivative with pronounced activity and toxicity. The anti-CD30 monoclonal antibody cAC10 conjugated to the cytotoxic agent monomethyl auristatin E, a synthetic analog of the tubulin polymerization inhibitor dolastatin.
Pathways	Cell Cycle/DNA Damage Others Pathway
Targets	ADC Related Microtubule

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