Merestinib dihydrochloride
| CAS No. | 1206801-37-7 | Cat. No. | BCP13049 |
| Name | Merestinib dihydrochloride | ||
| Synonyms | Merestinib 2Hcl;LY2801653 2Hcl;LY-2801653 dihydrochloride;LY2801653 dihydrochloride;LY 2801653 dihydrochloride; | ||
| Formula | C30H22F2N6O3.2(HCl) | M. Wt | 625.46 |
| Description | Merestinib dihydrochloride (LY2801653 dihydrochloride) is a potent, orally bioavailable c-Met inhibitor (Ki=2 nM) with anti-tumor activities. Merestinib dihydrochloride also has potent activity against MST1R (IC50=11 nM), FLT3 (IC50=7 nM), AXL (IC50=2 nM), MERTK (IC50=10 nM), TEK (IC50=63 nM), ROS1, DDR1/2 (IC50=0.1/7 nM) and MKNK1/2 (IC50=7 nM). | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | c Met | ||
Structure
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