Naloxegol
| CAS No. | 854601-70-0 | Cat. No. | BCP13157 |
| Name | Naloxegol | ||
| Synonyms | NKTR-118; NKTR 118; NKTR118; AZ-13337019; AZ13337019; AZ 13337019; UNII-44T7335BKE; | ||
| Formula | C34H53NO11 | M. Wt | 651.79 |
| Description | Naloxegol, also known as and NKTR-118 and AZ-13337019, is a peripherally-selective opioid antagonist for the treatment of opioid-induced constipation. It was approved in 2014 in adult patients with chronic, non-cancer pain. Chemically, naloxegol is a pegylated (polyethylene glycol-modified) derivative of α-naloxol. Specifically, the 5-α-hydroxyl group of α-naloxol is connected via an ether linkage to the free hydroxyl group of a monomethoxy-terminated n=7 oligomer of PEG. | ||
| Pathways | Neuro Signaling Pathway Hormone Pathay GPCR/G Protein | ||
| Targets | Opioid Receptor | ||
Structure
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