YK-4-279

  • Chemical Properties
CAS No. 1037184-44-3 Cat. No. BCP13213
Name YK-4-279
Synonyms YK 4-279;YK4-279;
Formula C17H13Cl2NO4 M. Wt 366.2
  • Biological Activity
Description ES-FLI1 is an oncogenic fusion protein found in Ewing’s sarcoma, a family of undifferentiated tumors that occur throughout the body. The binding of RNA helicase A (RHA) to ES-FLI1 promotes its oncogenic function. YK-4-279 is an inhibitor of protein-protein interactions between ES-FLI1 and RHA. At 10 μM, YK-4-279 blocks RHA binding to ES-FLI1 and induces apoptosis of a panel of Ewing’s sarcoma tumor cell lines with IC50 values ranging from 0.5-2 μM. At 1.5 mg per dose, YK-4-279 reduces the growth of Ewing’s sarcoma orthotopic xenografts in mice after treatment with the inhibitor for two weeks.
Pathways Cell Cycle/DNA Damage 
Targets DNA/RNA Synthesis 

Structure

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