Ramipril
| CAS No. | 87333-19-5 | Cat. No. | BCP13275 |
| Name | Ramipril | ||
| Synonyms | Tritace; Altace; Carasel; Ramace; Zabien; HOE-498; HOE498; | ||
| Formula | C23H32N2O5 | M. Wt | 416.51 |
| Description | Ramipril is an inhibitor of the angiotensin- converting enzyme that is reported to quickly hydrolyze into the active metabolite Ramiprilat. Angiotensin-converting enzyme (ACE) removes the C-terminal dipeptide from angiotensin I to form angiotensin II, a powerful vasoconstrictor. ACE is a key regulator of the renin-angiotensin system and an important drug target for the treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications in diabetes.1 Ramipril is a second generation ACE inhibitor that acts as a prodrug, which is hydrolyzed in vivo to the active metabolite ramiprilat. | ||
| Pathways | Protease/Metabolic Enzyme Hormone Pathay | ||
| Targets | RAAS/ACE | ||
Structure
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