盐酸舍曲林
| CAS号 | 79559-97-0 | 货号 | BCP28566 |
| 中文名 | 盐酸舍曲林 | ||
| 英文名 | Sertraline hydrochloride | ||
| 中文别名 | |||
| 英文别名 | Sertraline HCl; Sealdin; Adjuvin; Atruline; CP 51,974-1; Cp-51,974-1; CP 51,974; CP51,974; CP-51,974; Gladem; | ||
| 分子式 | C17H18Cl3N | 分子量 | 342.69 |
| 生物活性 | Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.Sertraline, also known as , is a selective serotonin uptake inhibitor that is used in the treatment of depression. Sertraline is primarily a serotonin reuptake inhibitor (SRI) with a binding affinity towards the serotonin transporter of Ki=2.8 nM or in that range. Sertraline is also a dopamine reuptake inhibitor, (<50 nmol/L). However, this is not considered a tight binding, and this action is only 10% of its potency as a monoamine reuptake inhibitor. It is a σ1 receptor agonist with 5% of its SRI potency, and an α1-adrenoreceptor antagonist with 1–10% of its SRI potency. | ||
| 信号通路 | Neuro Signaling Pathway | ||
| 靶 点 | SSRI | ||
结构式
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