Meclizine Dihydrochloride Monohydrate

  • Chemical Properties
CAS No. 31884-77-2 Cat. No. BCP13363
Name Meclizine Dihydrochloride Monohydrate
Synonyms Meclizine 2HCl H2O;Meclizine Dihydrochloride Hydrate;
Formula C25H27ClN2.2ClH.H2O M. Wt 481.89
  • Biological Activity
Description Meclizine Hydrochloride is the hydrochloride salt form of meclizine, a synthetic piperazine with anti-emetic, sedative and histamine H1 antagonistic properties. Meclizine hydrochloride blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial and gastrointestinal smooth muscles, including vasodilation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscles. Meclizine hydrochloride may exert its antiemetic effects by its anticholinergic actions or due to a direct effect on the medullary chemoreceptive trigger zone.
Pathways Neuro Signaling Pathway GPCR/G Protein 
Targets Histamine Receptor 

Structure

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