奥马索龙
| CAS号 | 1474034-05-3 | 货号 | BCP28609 |
| 中文名 | 奥马索龙 | ||
| 英文名 | Omaveloxolone | ||
| 中文别名 | |||
| 英文别名 | RTA408; RTA408; RTA-408;Nrf1-activator-1; | ||
| 分子式 | C33H44F2N2O3 | 分子量 | 554.71 |
| 生物活性 | Omaveloxolone, also known as RTA-408, is a member of the synthetic oleanane triterpenoid class of compounds and an activator of nuclear factor erythroid 2 [NF-E2]-related factor 2 (Nrf2, Nfe2l2), with potential chemopreventive activity. Upon administration, RTA 408 activates the cytoprotective transcription factor Nrf2. In turn, Nrf2 translocates to the nucleus, dimerizes with a small Maf protein (sMaf), and binds to the antioxidant response element (ARE). This induces the expression of a number of cytoprotective genes, including NAD(P)H quinone oxidoreductase 1 (NQO1), sulfiredoxin 1 (Srxn1), heme oxygenase-1 (HO1, HMOX1), superoxide dismutase 1 (SOD1), gamma-glutamylcysteine synthetase (gamma-GCS), thioredoxin reductase-1 (TXNRD1), glutathione S-transferase (GST), glutamate-cysteine ligase catalytic subunit (Gclc) and glutamate-cysteine ligase regulatory subunit (Gclm), and increases the synthesis of the antioxidant glutathione (GSH). | ||
| 信号通路 | Others Pathway NFκB | ||
| 靶 点 | Keap1 Nrf2 STING | ||
结构式
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