Nigericin

CAS No.	28380-24-7	Cat. No.	BCP13661
Name	Nigericin
Synonyms	Azalomycin M; Polyetherin A; Helixin C; Antibiotic K178; Antibiotic X464; 28643-80-3（Nigericin sodium salt）;
Formula	C40H68O11	M. Wt	724.97

Description	Nigericin is an antibiotic derived from Streptomyces hygroscopicus. Its isolation was described in the 1950s, and in 1968 the structure could be elucidated by X-ray crystallography. The structure and properties of nigericin are similar to the antibiotic monensin. Commercially it is obtained as a byproduct, or contaminant, at the fermentation of Geldanamycin. It is also called Polyetherin A, Azalomycin M, Helixin C, Antibiotic K178, Antibiotic X-464. Nigericin acts as an H+, K+, Pb2+ ionophore. Most commonly it is an antiporter of H+ and K+. In the past nigericin was used as an antibiotic active against gram positive bacteria. It inhibits the Golgi functions in Eukaryotic cells. Nigericin exhibits anticancer and anti-HIV activity.
Pathways	Ion Channel/Membrane Transporter Microbiology/Virology
Targets	Potassium Channel Antibiotic

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