Eflornithine

CAS No.	67037-37-0	Cat. No.	BCP13795
Name	Eflornithine
Synonyms	DFMO; MDL71782; MDL-71782; MDL71782; RMI71782; RMI-71782; RMI 71782; α-difluoromethylornithine;2-(Difluoromethyl)ornithine;
Formula	C6H12F2N2O2	M. Wt	182.17

Description	Eflornithine is a difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells.
Pathways	Others Pathway
Targets	Others

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