Acalisib
| CAS No. | 870281-34-8 | Cat. No. | BCP13804 |
| Name | Acalisib | ||
| Synonyms | GS-9820;GS 9820;GS9820; | ||
| Formula | C21H16FN7O | M. Wt | 401.4 |
| Description | p110beta/delta PI3K inhibitor GS-9820 inhibits the activity of PI3K, thereby preventing the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), which decreases tumor cell proliferation and induces cell death. PI3K-mediated signaling is often dysregulated in cancer cells; the targeted inhibition of PI3K is designed to preserve PI3K signaling in normal, non-neoplastic cells. | ||
| Pathways | PI3K/Akt/mTOR | ||
| Targets | PI3K | ||
Structure
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