Ibandronic acid

CAS No.	114084-78-5	Cat. No.	BCP13798
Name	Ibandronic acid
Synonyms	Ibandronate; 1-Hydroxy-3-(methylpentylamino)propylidene]diphosphonic Acid;
Formula	C9H25O7NP2	M. Wt	319.23

Description	Ibandronic Acid is a third-generation amino-bisphosphonate with anti-resorptive and anti-hypercalcemic activities. Ibandronic acid binds to and adsorbs onto the surface of hydroxyapatite crystals in the bone matrix, thereby preventing osteoclast resorption. This agent also inhibits farnesyl pyrophosphate synthase, an enzyme involved in the mevalonate pathway. Inhibition of this enzyme prevents the formation of isoprenoids, thereby leading to a reduction in the farnesylation and geranylgeranylation of signaling proteins of G protein-coupled signaling, and, eventually, inducing apoptosis of osteoclasts. By inhibiting osteoclast-mediated bone resorption, ibandronic acid increases bone mineral density, decreases bone remodeling and turnover, as well as reduces bone pain.
Pathways	Others Pathway
Targets	Others

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