(S)-(+)-Ketoprofen
| CAS No. | 22161-81-5 | Cat. No. | BCP13810 |
| Name | (S)-(+)-Ketoprofen | ||
| Synonyms | |||
| Formula | C16H14O3 | M. Wt | 254.28 |
| Description | Ketoprofenis a non-selective NSAID exhibiting IC50 of 0.5 μM and 2.33 μM for human recombinant COX-1 and COX-2, respectively. It is used for its antipyretic, analgesic, and anti-inflammatory properties by inhibiting cyclooxygenase-1 and -2 (COX-1 and COX-2) enzymes reversibly, which decreases production of pro-inflammatory prostaglandin precursors. Based on in vitro IC(50) COX-1:IC(50) COX-2 ratios, robenacoxib was COX-2 selective (ratio=32.2), diclofenac (ratio=3.9) and meloxicam (ratio=2.7) were only weakly COX-2 preferential, and ketoprofen (ratio=0.049) was COX-1 selective. | ||
| Pathways | Neuro Signaling Pathway | ||
| Targets | COX | ||
Structure
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