Zalcitabine

CAS No.	7481-89-2	Cat. No.	BCP13878
Name	Zalcitabine
Synonyms	DdC;Dideoxycytidine;2(acute),3(acute)-Dideoxycytidine;
Formula	C9H13N3O3	M. Wt	211.22

Description	Two human cell lines, WiDr (colon) and MCF-7 (breast) were exposed to ddC at 10 microM concentration for various lengths of time (18, 24, 48 and 72 h). On the WiDr cell line the dual effect of concentration and duration of exposure prior to irradiation was investigated. For MCF-7, ddC induced a significant modification of the dose response only with 24 and 48 h preincubation. It is phosphorylated in T cells and other HIV target cells into its active triphosphate form, ddCTP. This active metabolite works as a substrate for HIV reverse transcriptase, and also by incorporation into the viral DNA, hence terminating the chain elongation due to the missing hydroxyl group. Since zalcitabine is a reverse transcriptase inhibitor it possesses activity only against retroviruses.
Pathways	Microbiology/Virology Cell Cycle/DNA Damage
Targets	Reverse Transcriptase DNA/RNA Synthesis Antimetabolite HIV

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