CZC 25146
| CAS号 | 1191911-26-8 | 货号 | BCP14116 |
| 中文名 | CZC 25146 | ||
| 英文名 | CZC 25146 | ||
| 中文别名 | |||
| 英文别名 | CZC-25146;CZC25146; | ||
| 分子式 | C22H25FN6O4S | 分子量 | 488.54 |
| 生物活性 | CZC-25146 displayed a very clean profile, it inhibited only five kinases(PLK4, GAK, TNK1, CAMKK2 and PIP4K2C) with high potency, none of which have been classified as predictors of genotoxicity or hematopoietic toxicity. CZC-25146 neither caused cytotoxicity in human cortical neurons at concentrations below 5 μM over a seven-day treatment in culture nor did it block neuronal development in vitro. CZC-25146 possesses favorable pharmacokinetic properties, such as a volume of distribution of 5.4 L/kg and a clearance of 2.3 L/hr/kg that render it suitable for in-vivo studies. | ||
| 信号通路 | Others Pathway | ||
| 靶 点 | LRRK2 | ||
结构式
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