Debio-1347
| CAS No. | 1265229-25-1 | Cat. No. | BCP14354 |
| Name | Debio-1347 | ||
| Synonyms | FF-284;FF 284;FF284;Debio 1347;Debio1347;CH 518328;CH5183284;CH-5183284; | ||
| Formula | C20H16N6O | M. Wt | 356.38 |
| Description | Debio-1347, also known as FF284 and CH5183284, is an orally bioavailable inhibitor of the fibroblast growth factor receptor subtypes 1 (FGFR-1), 2 (FGFR-2) and 3 (FGFR-3), with potential antineoplastic activity. FGFR inhibitor debio 1347 binds to and inhibits FGFR-1, -2, and -3, which result in the inhibition of FGFR-mediated signal transduction pathways. This leads to the inhibition of both tumor cell proliferation and angiogenesis, and causes cell death in FGFR-overexpressing tumor cells. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | FGFR | ||
Structure
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