JNJ-42153605
| CAS No. | 1254977-87-1 | Cat. No. | BCP28688 |
| Name | JNJ-42153605 | ||
| Synonyms | JNJ 42153605; JNJ42153605; | ||
| Formula | C22H23F3N4 | M. Wt | 400.44 |
| Description | JNJ-42153605 is a potent and selective mGlu2 receptor PAM with an acceptable pharmacokinetic profile in rodent and nonrodent species. JNJ-42153605 showed centrally mediated in vivo effectivity in models sensitive to mGlu2 receptor modulation such as sleep−wake electroencephalogram (sw-EEG) in rats,34 showing suppressed REM sleep during the first 4 h after oral administration of a 3 mg/kg dose. | ||
| Pathways | Neuro Signaling Pathway GPCR/G Protein | ||
| Targets | mGluR | ||
Structure
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