GDC-0623
| CAS No. | 1168091-68-6 | Cat. No. | BCP28689 |
| Name | GDC-0623 | ||
| Synonyms | GDC0623;GDC 0623; | ||
| Formula | C16H14FIN4O3 | M. Wt | 456.21 |
| Description | GDC-0623 is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki=0.13 nM, +ATP), and displays 6-fold weaker potency against HCT116 (KRAS (G13D), EC50=42 nM) versus A375 (BRAFV600E, EC50=7 nM). | ||
| Pathways | MAPK Pathway | ||
| Targets | MEK/ERK | ||
Structure
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