赛特铂
| CAS号 | 129580-63-8 | 货号 | BCP14387 |
| 中文名 | 赛特铂 | ||
| 英文名 | Satraplatin | ||
| 中文别名 | 顺式-二氯-反式-二乙酸-氨-环己胺合铂; 沙铂;沙曲铂; | ||
| 英文别名 | BMS182751; BMS 182751; BMS-182751; JM 216; JM-216; JM216; BMY45594; POplat; | ||
| 分子式 | C10H22Cl2N2O4Pt | 分子量 | 500.28 |
| 生物活性 | Satraplatin is the first orally active platinum-based chemotherapeutic drug. Other available platinum analogues—cisplatin, carboplatin, and oxaliplatin—must be given intravenously. It is made available in the United States jointly by Spectrum Pharmaceuticals and GPC Biotech under the name SPERA (SatraPlatin Expanded Rapid Access). The drug has also been used in the treatment of lung and ovarian cancers. The proposed mode of action is that the compound binds to the DNA of cancer cells rendering them incapable of dividing. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | DNA Alkylator/Crosslinker | ||
结构式
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