非阿尿苷
| CAS号 | 69123-98-4 | 货号 | BCP14466 |
| 中文名 | 非阿尿苷 | ||
| 英文名 | Fialuridine | ||
| 中文别名 | |||
| 英文别名 | FIAU; DRG 0098; DRG0098; DRG-0098; Fluoroiodoarauridine; | ||
| 分子式 | C9H10FIN2O5 | 分子量 | 372.09 |
| 生物活性 | Fialuridine is a DNA-directed DNA polymerase inhibitor potentially for the treatment of HBV infection. Fialuridine induces acute liver failure in chimeric TK-NOG mice: a model for detecting hepatic drug toxicity prior to human testing. Fialuridine is phosphorylated and inhibits DNA synthesis in isolated rat hepatic mitochondria. Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts. | ||
| 信号通路 | Microbiology/Virology | ||
| 靶 点 | HBV | ||
结构式
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