Epacadostat

CAS No.	1204669-58-8	Cat. No.	BCP14546
Name	Epacadostat
Synonyms	INCB024360; INCB 024360; INCB-024360; INCB24360; INCB-24360; INCB 24360; IDO inhibitor 1;
Formula	C11H13BrFN7O4S	M. Wt	438.23

Description	Epacadostat, also known as INCB024360 or INCB24360, is an orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase (IDO1), with potential immunomodulating and antineoplastic activities. INCB024360 targets and binds to IDO1, an enzyme responsible for the oxidation of tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, INCB024360 increases and restores the proliferation and activation of various immune cells, including dendritic cells (DCs), NK cells, and T-lymphocytes, as well as interferon (IFN) production, and a reduction in tumor-associated regulatory T cells (Tregs).
Pathways	Protease/Metabolic Enzyme
Targets	IDO

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