寡霉素A

  • 化学数据
CAS号 579-13-5 货号 BCP14686
中文名 寡霉素A
英文名 Oligomycin A
中文别名
英文别名 MCH 32; MCH 32; MCH 32;
分子式 C45H74O11 分子量 791.06
  • 用途
生物活性 Oligomycin A, also known as MCH 32, is an inhibitor of ATP synthase. Oligomycin A inhibits ATP synthase by blocking its proton channel (Fo subunit), which is necessary for oxidative phosphorylation of ADP to ATP (energy production). The inhibition of ATP synthesis by oligomycin A will significantly reduce electron flow through the electron transport chain; however, electron flow is not stopped completely due to a process known as proton leak or mitochondrial uncoupling. This process is due to facilitated diffusion of protons into the mitochondrial matrix through an uncoupling protein such as thermogenin, or UCP1.
信号通路 Ion Channel/Membrane Transporter 
靶 点 ATPase 

结构式

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