寡霉素A
CAS号 | 579-13-5 | 货号 | BCP14686 |
中文名 | 寡霉素A | ||
英文名 | Oligomycin A | ||
中文别名 | |||
英文别名 | MCH 32; MCH 32; MCH 32; | ||
分子式 | C45H74O11 | 分子量 | 791.06 |
生物活性 | Oligomycin A, also known as MCH 32, is an inhibitor of ATP synthase. Oligomycin A inhibits ATP synthase by blocking its proton channel (Fo subunit), which is necessary for oxidative phosphorylation of ADP to ATP (energy production). The inhibition of ATP synthesis by oligomycin A will significantly reduce electron flow through the electron transport chain; however, electron flow is not stopped completely due to a process known as proton leak or mitochondrial uncoupling. This process is due to facilitated diffusion of protons into the mitochondrial matrix through an uncoupling protein such as thermogenin, or UCP1. | ||
信号通路 | Ion Channel/Membrane Transporter | ||
靶 点 | ATPase |
结构式

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