FIIN-3
| CAS No. | 1637735-84-2 | Cat. No. | BCP28774 |
| Name | FIIN-3 | ||
| Synonyms | FIIN3; FIIN 3; | ||
| Formula | C34H36Cl2N8O4 | M. Wt | 691.61 |
| Description | FIIN-3 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor. FIIN-3 is the first inhibitor that can potently inhibit the proliferation of cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2, which confer resistance to first-generation clinical FGFR inhibitors such as NVP-BGJ398 and AZD4547. FIIN-3 has the unprecedented ability to inhibit both the EGF receptor (EGFR) and FGFR covalently by targeting two distinct cysteine residues. FIIN-3 bound with FGFR4 V550L and EGFR L858R. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway | ||
| Targets | EGFR FGFR | ||
Structure
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