Pizotifen

Description	Pizotifen, is a benzocycloheptane based drug used as a medicine, primarily as a preventative to reduce the frequency of recurrent migraine headaches . Pizotifen proved to be a highly selective 5-HT receptor blocking agent both in vivo (on saphenous veins) and in vitro (on saphenous veins and basilar arteries) from dogs and humans . Three groups of pregnant mice were treated daily with oral doses (0.24, 0.6 and 1.2 mg/kg) of pipethiadene and pizotifen from day 4 to day 16 of gestation. The following parameters were investigated: reproductive health of the dams, external, skeletal and visceral malformations of fetuses and frequencies of micronuclei and chromosome aberrations in bone marrow cells of dams. Oral administration of Pipethiadene or Pizotifen produced no teratogenic effects. However, the significant reduction of fetal weight after all doses of Pipethiadene or Pizotifen was found to correlate well with the decreased values of the mitotic indices of bone marrow cells of mice.
Pathways	Neuro Signaling Pathway GPCR/G Protein
Targets	5 HT Receptor/Serotonin Receptor

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