BMS-687453
| CAS No. | 1000998-59-3 | Cat. No. | BCP14808 |
| Name | BMS-687453 | ||
| Synonyms | BMS 687453;BMS687453; | ||
| Formula | C22H21ClN2O6 | M. Wt | 444.86 |
| Description | BMS-687453 is a potent and selective peroxisome proliferator activated receptor (PPAR) alpha agonist. with an EC(50) of 10 nM for human PPARalpha and approximately 410-fold selectivity vs human PPARgamma in PPAR-GAL4 transactivation assays. BMS-687453 demonstrated an excellent pharmacological and safety profile in preclinical studies and thus was chosen as a development candidate for the treatment of atherosclerosis and dyslipidemia. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | PPAR | ||
Structure
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