LRRK2-IN-1
| CAS号 | 1234480-84-2 | 货号 | BCP14860 |
| 中文名 | LRRK2-IN-1 | ||
| 英文名 | LRRK2-IN-1 | ||
| 中文别名 | |||
| 英文别名 | LRRK2-IN 1; LRRK2-IN1; | ||
| 分子式 | C31H38N8O3 | 分子量 | 570.69 |
| 生物活性 | LRRK2-IN-1 is a potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2). LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1. LRRK2-IN-1 demonstrates potent anti-cancer activity including inhibition of cancer cell proliferation, migration, and invasion as well as induction of apoptosis and cell cycle arrest. LRRK2-IN-1 suppresses DCLK1 kinase activity and downstream DCLK1 effector c-MYC, and demonstrate that DCLK1 kinase activity is a significant factor in resistance to LRRK2-IN-1. | ||
| 信号通路 | Others Pathway | ||
| 靶 点 | LRRK2 | ||
结构式
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