PF-06447475
| CAS No. | 1527473-33-1 | Cat. No. | BCP14890 |
| Name | PF-06447475 | ||
| Synonyms | PF06447475;PF 06447475; | ||
| Formula | C17H15N5O | M. Wt | 305.33 |
| Description | PF-06447475 was sufficiently potent in the LRRK2 whole cell assay (WCA; IC50=25 nM) (pS935 end point) to warrant additional profiling. Oral administration of PF-06447475 twice daily for 15 days was well tolerated at doses up to 60 mg kg-1 day-1 (31-fold Cave,0.24h; 70-fold Cmax) with only minimal alterations in RBC parameters, electrolytes, and food consumption without concurrent effects on body weight. | ||
| Pathways | Others Pathway | ||
| Targets | LRRK2 | ||
Structure
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