NSC 213841

CAS No.	178606-66-1	Cat. No.	BCP14895
Name	NSC 213841
Synonyms	SLC-0111; SLC0111; SLC 0111; MST104; MST-104; MST 104;NSC-213841;NSC213841;U-104;U104;U 104;
Formula	C13H12FN3O3S	M. Wt	309.32

Description	SLC-0111, also known as U-104, MST-104 and NSC 213841, is an inhibitor of transmembrane CAIX (Ki = 45.1 nM) and CAXII (Ki = 4.5 nM). Carbonic anhydrase IX (CAIX) is a hypoxia-inducible protein that regulates cellular pH to promote cancer cell survival and invasion in hypoxic microenvironments and is a biomarker of poor prognosis for breast cancer metastasis and survival. CAIX is a critical mediator of the expansion of breast CSCs in hypoxic niches by sustaining the mesenchymal and 'stemness' phenotypes of these cells, making CAIX an important therapeutic target for selectively depleting breast CSCs.
Pathways	Protease/Metabolic Enzyme
Targets	Carbonic Anhydrase

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