CO-1686 hydrobromide
| CAS No. | 1446700-26-0 | Cat. No. | BCP28816 |
| Name | CO-1686 hydrobromide | ||
| Synonyms | CO 1686 hydrobromide;CO1686 hydrobromide;Rociletinib hydrobromide; AVL-301 hydrobromide; CNX419 hydrobromide;AVL301 hydrobromide; CNX-419 hydrobromide;AVL 301 hydrobromide; CNX 419 hydrobromide; | ||
| Formula | C27H29BrF3N7O3 | M. Wt | 636.46 |
| Description | CO-1686 hydrobromide is an orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M, and the Ki values for EGFR L858R/T790M and EGFR WT are 21.5 nM and 303.3 nM, respectively. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway | ||
| Targets | EGFR | ||
Structure
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