Cysteamine hydrochloride

CAS No.	156-57-0	Cat. No.	BCP15033
Name	Cysteamine hydrochloride
Synonyms	(beta)-MEA Hydrochloride;(beta)-Mercaptoethylamine Hydrochloride;2-Aminoethanethiol Hydrochloride;2-Mercaptoethylamine Hydrochloride;Decarboxycysteine Hydrochloride;MEA Hydrochloride;Thioethanolamine;
Formula	C2H8ClNS	M. Wt	113.61

Description	Cysteamine has been shown to increase intracellular glutathione levels in cystinotic cells, thus restoring the altered redox state of the cells. Also increased rates of apoptosis in cystinotic cells, which are thought to be the result of increased caspase 3 and protein kinase Cε activity, is counteracted by Cysteamine administration. Cysteamine has antioxidant properties as a result of increasing glutathione production. Cysteamine is an excellent scavenger of OH and HOCl; it also reacts with H2O2. Cysteamine increases the production of several heat shock proteins (HSP), including the murine Hsp40. Cysteamine exerts a dose-dependent effect on the doxorubicin-induced death of cancer cells, measured in both HeLa cells and B16 cells, whereas Cysteamine treatment alone had no influence on cell survival. In addition, in a doxorubicin-resistant breast cancer cell line, the addition of Cysteamine to doxorubicin results in a dramatic increase in cell death . Cysteamine (100 μM) significantly is
Pathways	Others Pathway
Targets	Autophagy

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