KU59403
| CAS No. | 845932-30-1 | Cat. No. | BCP28847 |
| Name | KU59403 | ||
| Synonyms | KU-59403; KU 59403; | ||
| Formula | C29H32N4O4S2 | M. Wt | 564.72 |
| Description | KU59403 is a potent and selective ATM (Ataxia telangiectasia mutated) inhibitor with with potential anticancer activity. KU59403 was not cytotoxic to human cancer cell lines (SW620, LoVo, HCT116, and MDA-MB-231) per se but significantly increased the cytotoxicity of topoisomerase I and II poisons: camptothecin, etoposide, and doxorubicin. | ||
| Pathways | Cell Cycle/DNA Damage PI3K/Akt/mTOR | ||
| Targets | ATM/ATR | ||
Structure
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