L189
| CAS No. | 64232-83-3 | Cat. No. | BCP15116 |
| Name | L189 | ||
| Synonyms | L-189;L 189; | ||
| Formula | C11H10N4OS | M. Wt | 246.29 |
| Description | L189 is a DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding. L189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L189 specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | DNA/RNA Synthesis | ||
Structure
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