BLU9931
| CAS No. | 1538604-68-0 | Cat. No. | BCP15296 |
| Name | BLU9931 | ||
| Synonyms | BLU-9931;BLU 9931; | ||
| Formula | C26H22Cl2N4O3 | M. Wt | 509.38 |
| Description | BLU9931 is exquisitely selective for FGFR4 versus other FGFR family members and all other kinases. BLU9931 shows remarkable antitumor activity in mice bearing an HCC tumor xenograft that overexpresses FGF19 due to amplification as well as a liver tumor xenograft that overexpresses FGF19 mRNA but lacks FGF19 amplification. Approximately one third of patients with HCC whose tumors express FGF19 together with FGFR4 and its coreceptor klotho β (KLB) could potentially respond to treatment with an FGFR4 inhibitor. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | FGFR | ||
Structure
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