H-89 Dihydrochloride

  • Chemical Properties
CAS No. 130964-39-5 Cat. No. BCP15626
Name H-89 Dihydrochloride
Synonyms Protein kinase inhibitor H-89 dihydrochloride;H-89; H89; H 89 2HCl;
Formula C20H22BrCl2N3O2S M. Wt 519.28
  • Biological Activity
Description H-89 is a specific adenylyl cyclase inhibitor (DDA) and a cyclic AMP-dependent protein kinase inhibitor. H-89 blocks the action of equine growth hormone on in vitro maturation of equine oocytes. H-89 decreases the gain of excitation-contraction coupling and attenuates calcium sparks in the absence of beta-adrenergic stimulation. H-89 potentiates adipogenesis in 3T3-L1 cells by activating insulin signaling independently of protein kinase A.
Pathways GPCR/G Protein Wnt/Stem Cell 
Targets PKA 

Structure

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