Naloxegol oxalate

CAS No.	1354744-91-4	Cat. No.	BCP15773
Name	Naloxegol oxalate
Synonyms	NKTR-118; NKTR 118; NKTR118; AZ-13337019; AZ13337019; AZ 13337019; UNII-65I14TNM33;
Formula	C34H53NO11.C2H2O4	M. Wt	741.82

Description	Naloxegol, also known as and NKTR-118 and AZ-13337019, is a peripherally-selective opioid antagonist for the treatment of opioid-induced constipation. It was approved in 2014 in adult patients with chronic, non-cancer pain. Chemically, naloxegol is a pegylated (polyethylene glycol-modified) derivative of α-naloxol. Specifically, the 5-α-hydroxyl group of α-naloxol is connected via an ether linkage to the free hydroxyl group of a monomethoxy-terminated n=7 oligomer of PEG.
Pathways	Neuro Signaling Pathway Hormone Pathay GPCR/G Protein
Targets	Opioid Receptor

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