沙库比曲钠
| CAS号 | 149690-05-1 | 货号 | BCP15909 |
| 中文名 | 沙库比曲钠 | ||
| 英文名 | Sacubitril Sodium Salt | ||
| 中文别名 | AHU-377 钠盐; | ||
| 英文别名 | Sacubitril sodium;AHU337; AHU-337; AHU 337; LCZ696; LCZ 696; LCZ696; | ||
| 分子式 | C24H28NNaO5 | 分子量 | 433.47 |
| 生物活性 | Sacubitril is angiotensin receptor neprilysin inhibitor being studied for use in combination with valsartan for heart failure. Sacubitril is a prodrug that is activated to LBQ657 by de-ethylation via esterases. LBQ657 inhibits the enzyme neprilysin, which is responsible for the degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides that work mainly by reducing blood volume. | ||
| 信号通路 | Protease/Metabolic Enzyme GPCR/G Protein | ||
| 靶 点 | Angiotensin Receptor Neprilysin | ||
结构式
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