cyclo(RGDyK)
| CAS No. | 250612-42-1 | Cat. No. | BCP15929 |
| Name | cyclo(RGDyK) | ||
| Synonyms | |||
| Formula | C31H43F6N9O12 | M. Wt | 847.72 |
| Description | Cyclo(RGDyK) is a selective and potent αVβ3 integrin inhibitor with IC50 value of 20 nM. The αVβ3 integrin, expressed on various malignant human tumors and on endothelial cells, plays an important role in tumor-induced angiogenesis and tumor metastasis. Therefore, αVβ3 integrin is a potential therapeutic target for tumor disease. Inhibition of αVβ3 integrin by αVβ3 antagonists not only blocked blood vessel formation but further led to tumor regression. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | Integrin | ||
Structure
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