BG45
| CAS No. | 926259-99-6 | Cat. No. | BCP15990 |
| Name | BG45 | ||
| Synonyms | BG-45;BG 45; | ||
| Formula | C11H10N4O | M. Wt | 214.22 |
| Description | BG45 is a potent and selective HDAC3 inhibitor inhibitor with selectivity for HDAC3 (IC50 = 289 nM) over HDAC1, 2. BG45 did not inihibit HDAC6. BG45 signigicantly inhibited tumor growth in a mouse model of multiple myeloma either alone and synergistically in combination with bortezomib. HDAC3 represents a promising therapeutic target, and validate a prototype novel HDAC3 inhibitor BG45 in MM. | ||
| Pathways | Cell Cycle/DNA Damage Epigenetics | ||
| Targets | HDAC | ||
Structure
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