BAY 41-2272
| CAS号 | 256376-24-6 | 货号 | BCP16012 |
| 中文名 | BAY 41-2272 | ||
| 英文名 | BAY 41-2272 | ||
| 中文别名 | |||
| 英文别名 | BAY-41-2272; BAY41-2272; BAY412272; BAY-412272; BAY 412272; | ||
| 分子式 | C20H17FN6 | 分子量 | 360.39 |
| 生物活性 | BAY 41-2272 is a a soluble guanylate cyclase stimulator (sGC stimulator). BAY 41-2272 inhibits platelet aggregation (IC50 = 36 nM), induces relaxation of phenylephrine-preconstricted rabbit aorta rings (IC50 = 304 nM), and reduces proliferation in smooth muscle.2,3 BAY 41-2272 is effective in vivo. BAY 41-2272 inhibits vascular smooth muscle growth through the cAMP-dependent protein kinase and cGMP-dependent protein kinase pathways. BAY 41-2272 inhibits the development of chronic hypoxic pulmonary hypertension in rats. | ||
| 信号通路 | GPCR/G Protein | ||
| 靶 点 | Guanylate Cyclase | ||
结构式
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